RSSRSS
|
|

Monthly vitamin D supplement safe and effective

NEW YORK (Reuters Health) - A single high dose of vitamin D given every four weeks is as safe as smaller daily or weekly doses, and is as effective in achieving adequate circulating levels of the vitamin, according to a study conducted in Israel.

Tuesday, October 21, 2008

NEW YORK (Reuters Health) - A single high dose of vitamin D given every four weeks is as safe as smaller daily or weekly doses, and is as effective in achieving adequate circulating levels of the vitamin, according to a study conducted in Israel.

To prevent fractures in older patients, the level of the active metabolite of vitamin D -- that is, 25-hydroxyvitamin D -- should be higher than 30 nanograms per milliliter, Dr. Sophia Ish-Shalom and colleagues explain in the Journal of Clinical Endocrinology and Metabolism.

While monthly dosing could make it easier for people to stick to regular vitamin D supplementation, the researchers were concerned that a large dose might lead to a spike in calcium levels in the blood -- which could cause problems.

To check, the team conducted a clinical trial with 48 women, 81 years of age on average, who had undergone surgery to repair a hip fracture, to compare three dosing regimens of vitamin D supplementation: 1,500 International Units once daily, 10,500 IU once weekly, or 45,000 IU every 28 days.

After two months, blood levels of 25-hydroxyvitamin D were similar at 33.2, 29.2, and 37.1 nanograms per milliliter, respectively.

A single instance of excessive blood levels of calcium occurred, in a patient assigned to the daily supplement.

Ish-Shalom, at Rambam Medical Center in Haifa, Israel, and associates conclude that "the choice of dose frequency can be based on whichever approach will optimize an individual's adherence" to regular vitamin D supplementation.

SOURCE: Journal of Clinical Endocrinology and Metabolism, September 2008.


See More Health Articles

Members can post comments, receive benefits.

USERNAME PASSWORD forgot it?

 
 


More From ELDR Magazine  

HomeAbout ELDRAdvertise with ELDRMedia KitELDR PartnersWriters' GuidelinesContact UsPrivacy PolicyTerms & ConditionsSite Credits